https://www.treadlab.org/team-grad daily 0.75 2023-07-03 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/ba6e217c-d8e3-4ab0-b8a6-c70ae4ef9d3f/Screen+Shot+2018-05-04+at+1.21.06+PM.png Graduate Students - Shabnam Hossein, PhD, MA Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1595963270228-UNYNEQ156CZYAH4MZAOR/neuralnets.jpeg Graduate Students - Victoria Lawlor, MA Victoria graduated from Northeastern University with a B.S. in Psychology and minor in Computer Science. Before joining the TReAD lab, she worked as a student intern and co-op research assistant at McLean Hospital, where she used EEG and computational modeling to investigate learning and memory processes in adults with depression. Victoria is interested in using neuroimaging and computational methods to probe dysfunctional value-based decision-making in depression and anxiety. She is also interested identifying linguistic markers of psychopathology using natural language processing. https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1599698765158-4OOSXFHPR1VBBU4T4K9V/sarah.jpg Graduate Students - Sarah Etuk, MA Sarah graduated with a BA in neuroscience from Pomona college, and then completed the NIH PREP program at Northwestern University. Her work in the lab has focused on examining the role of inflammation and immunometabolism in context of motivational impairments in mood disorders. She is also interested in the neurobiological consequences of early life adversity and their role in the development of mental illness. https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/ffdabe96-6486-479e-90a4-aa9ce92e9f83/Image+d%E2%80%99iOS.jpg Graduate Students - Marta Migo, MA Marta graduated from New York University with a B.A. in Psychology, a B.F.A. in Drama, and minors in Computer Science and Philosophy. She then worked as a Clinical Research Coordinator at Harvard Medical School/Massachusetts General Hospital for two years, in the Division of Neurotherapeutics. Currently, Marta is interested in using neuroimaging and computational psychiatry techniques to study free and perseverative thought patterns, such as worry and rumination, in mood and anxiety-related disorders. https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/efd31b9c-cea5-47c9-9d26-5e2c2774f6af/31719424_10160198739210431_3168881988304109568_n+%281%29.jpg Graduate Students - Shosuke Suzuki, MA Shosuke graduated from UCLA with a B.S. in Neuroscience. Before joining the TReAD lab, he spent 3 years working as a research assistant at Yale University, where he gained experience running multi-session clinical trials with fMRI and EEG components in Substance Use Disorders. He is primarily interested in using ecological paradigms to examine the interface between motivation and action. Outside of lab, he enjoys cooking, bouldering, and meditating. https://www.treadlab.org/tools daily 0.75 2025-11-21 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Tools https://www.treadlab.org/publications daily 0.75 2025-07-09 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Publications https://www.treadlab.org/participate-in-research daily 0.75 2024-10-15 https://images.squarespace-cdn.com/content/v1/5ce435d6bea1ed00016ba287/1558964652247-5MWXNMFZVOPGE4TY6U2Q/MHeiderich_ReflexionenZwei-05-copy.jpg Participate in Research https://www.treadlab.org/team-ugras daily 0.75 2023-07-03 https://www.treadlab.org/team-postdocs daily 0.75 2023-07-03 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/0f86eb5f-0034-4c2b-a335-c211a6400ab1/JonRyan_resize.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1595963270228-UNYNEQ156CZYAH4MZAOR/neuralnets.jpeg https://www.treadlab.org/team-staff daily 0.75 2022-08-24 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/eac4cd2b-7dec-4c00-bfb2-c02e5fbaa16c/Screen+Shot+2022-06-22+at+3.07.04+PM.png Research Staff - Shiyin Liu, BS Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1595963270228-UNYNEQ156CZYAH4MZAOR/neuralnets.jpeg Research Staff - Make it stand out Jessica Kubert, BA https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1595963270228-UNYNEQ156CZYAH4MZAOR/neuralnets.jpeg Research Staff - Make it stand out Samantha Betters, BS https://www.treadlab.org/team-directors daily 0.75 2022-10-05 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1599698704154-3U6TOQ61VFNY6S61W9M8/IMG_3298-e1588279039942-830x1024.jpg Directors - Michael T Treadway, PhD Dr. Treadway is a clinical psychologist and neuroscientist focused on understanding the molecular and circuit-level mechanisms of psychiatric symptoms related to mood, anxiety, and decision-making. He received his PhD in clinical psychology from Vanderbilt University in 2012, and completed his clinical internship and post-doc at McLean Hospital/Harvard Medical School. As Director of the Translational Research in Affective Disorders Laboratory (TReADLab) in the Department of Psychology at Emory University, Dr. Treadway’s research employs a variety of methods, including multimodal neuroimaging techniques (fMRI, MRS, and PET), behavioral paradigms, computational modeling, and clinical/personality assessment. A particular interest has been the assessment of reward motivation in psychiatric populations, for which Dr. Treadway has developed several laboratory tasks, including the Effort-Expenditure for Rewards Task (EEfRT). Email: mtreadway@emory.edu Office: (404) 727-3166 Fax: (404) 727-0372 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1600792716599-L0JP4ADUCGJ6IG601S7I/Jess_temp+photo.jpg Directors - Jessica A Cooper, PhD Dr. Jessica Cooper is an Assistant Professor in the Department of Psychiatry and Behavioral Sciences at Emory University with research interests in motivation and decision making. She received her PhD from the University of Texas in 2016, where she primarily studied decision making and reinforcement learning in healthy aging. Her work in the TReAD lab focuses on characterizing neurobiological and computational mechanisms of motivation and effort-based decision making in both healthy and clinical populations. She employs a variety of methods, including computational modeling, behavioral paradigms, functional magnetic resonance imaging (fMRI), and ecological momentary assessment (EMA). Jess has been funded by a Ruth L. Kirschstein Postdoctoral Individual National Research Service Award (NRSA) as well as K01 award from the National Institute of Mental Health. Email: j.cooper@emory.edu https://www.treadlab.org/news daily 0.75 2026-03-09 https://www.treadlab.org/alumni daily 0.75 2023-07-03 https://www.treadlab.org/grad-app daily 0.75 2025-07-09 https://www.treadlab.org/vet daily 0.75 2023-10-10 https://www.treadlab.org/undergrad-research-assistants daily 0.75 2026-03-31 https://www.treadlab.org/effort-randomized-vet daily 0.75 2023-09-26 https://www.treadlab.org/team-1 daily 0.75 2026-03-09 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/9b3027af-6990-4f18-adc9-b67691b7af49/IMG_3298-e1588279039942-830x1024.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/d80ae7d5-86ed-47d5-a441-be79370fdefb/Jess_temp+photo.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/0f86eb5f-0034-4c2b-a335-c211a6400ab1/JonRyan_resize.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/eb146711-9cfa-4fda-8241-5d42e1af2a1f/Wenwu_Sun.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/48390e79-fe41-49a9-a0d4-9d35201439fb/31719424_10160198739210431_3168881988304109568_n+%281%29.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/29275638-1a35-48c0-9c20-aefcac2fe81b/summer_cropped_img.png https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/9d4dc208-ead0-4a95-9d01-875056e37616/sarah.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/45aaee07-5212-4045-9417-15002b15e684/Image+d%E2%80%99iOS.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/ffdcd1c2-05db-4d56-9638-611c021642df/neuralnets.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/5ada6129-4813-4c86-bd31-d56afb8de08a/IMG_0741.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/9e136f24-5f4c-4425-a760-47d38867303b/Aje.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/cf228052-af65-44d3-8051-1bb29bb16bc3/CC_headshot.JPG https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/5e63fcbf-0b0e-4542-8808-dc56305178cd/IMG_1800+%281%29.JPG https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/ffdcd1c2-05db-4d56-9638-611c021642df/neuralnets.jpg https://www.treadlab.org/team-directors-1 daily 0.75 2023-10-19 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1599698704154-3U6TOQ61VFNY6S61W9M8/IMG_3298-e1588279039942-830x1024.jpg Directors (Copy) - Michael T Treadway, PhD Dr. Treadway is a clinical psychologist and neuroscientist focused on understanding the molecular and circuit-level mechanisms of psychiatric symptoms related to mood, anxiety, and decision-making. He received his PhD in clinical psychology from Vanderbilt University in 2012, and completed his clinical internship and post-doc at McLean Hospital/Harvard Medical School. As Director of the Translational Research in Affective Disorders Laboratory (TReADLab) in the Department of Psychology at Emory University, Dr. Treadway’s research employs a variety of methods, including multimodal neuroimaging techniques (fMRI, MRS, and PET), behavioral paradigms, computational modeling, and clinical/personality assessment. A particular interest has been the assessment of reward motivation in psychiatric populations, for which Dr. Treadway has developed several laboratory tasks, including the Effort-Expenditure for Rewards Task (EEfRT). Email: mtreadway@emory.edu Office: (404) 727-3166 Fax: (404) 727-0372 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1600792716599-L0JP4ADUCGJ6IG601S7I/Jess_temp+photo.jpg Directors (Copy) - Jessica A Cooper, PhD Dr. Jessica Cooper is an Assistant Professor in the Department of Psychiatry and Behavioral Sciences at Emory University with research interests in motivation and decision making. She received her PhD from the University of Texas in 2016, where she primarily studied decision making and reinforcement learning in healthy aging. Her work in the TReAD lab focuses on characterizing neurobiological and computational mechanisms of motivation and effort-based decision making in both healthy and clinical populations. She employs a variety of methods, including computational modeling, behavioral paradigms, functional magnetic resonance imaging (fMRI), and ecological momentary assessment (EMA). Jess has been funded by a Ruth L. Kirschstein Postdoctoral Individual National Research Service Award (NRSA) as well as K01 award from the National Institute of Mental Health. Email: j.cooper@emory.edu https://www.treadlab.org/team-postdocs-1 daily 0.75 2023-10-19 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/0f86eb5f-0034-4c2b-a335-c211a6400ab1/JonRyan_resize.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1595963270228-UNYNEQ156CZYAH4MZAOR/neuralnets.jpeg https://www.treadlab.org/about-us daily 1.0 2026-03-24 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/89418f5b-c550-4d95-ac68-1cebcae320a3/IMG_3794.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/ab626644-19d8-402b-8123-6e6add36b00e/IMG_5397.jpg https://www.treadlab.org/research-coordinator-job-posting-2024 daily 0.75 2024-02-08 https://www.treadlab.org/ebdm1 daily 0.75 2024-03-11 https://www.treadlab.org/ebdm2 daily 0.75 2024-03-11 https://www.treadlab.org/research-edited daily 0.75 2024-03-11 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/e24fc934-c9c7-49a9-a05f-b0bc43ef0567/InflammatoryMarkersofDepression.png https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/b71097c7-225a-4a4b-8436-cbea86ed94d7/MultilevelMechanismsofBehavioralActivationTherapy.png https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/c75e5dd1-77a6-4ea0-baac-e5a683faaa81/MechanismsofAnhedonia.png https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/8c7beea5-3e4c-4a3b-afd2-79dca05835f6/StressNeuroplasticityandReinforcementLearning.png https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/6d308795-370b-4bc6-a947-35e18ace141c/BrainStudiesofDecisionMakingwithTemporalInterference.png https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/2b2e7fd5-8963-46ee-8e1b-74ce3cf4c272/MotivationforRewardintheVirtualEnvironment.png https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/8628ea5d-4050-49ef-a1ee-15a6e1e58343/NeuralMechanismsofMotivationandDecisionMaking.png https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/816a6a10-860d-4258-8cf3-337a8164995d/TransdiagnosticImmuneEffects.png https://www.treadlab.org/veet1 daily 0.75 2024-03-28 https://www.treadlab.org/veet2 daily 0.75 2024-03-26 https://www.treadlab.org/veetdemo daily 0.75 2024-05-07 https://www.treadlab.org/mental-health-resources daily 0.75 2024-10-17 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/16199318-e5de-44f2-85a2-5b33cfe6d963/TReADLab+Resources_temporally_relevant_pg1+%281%29.jpg https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/82dc74c9-c837-4d8b-afb4-e18685f970d8/TReADLab+Resources_temporally_relevant_pg2.jpg https://www.treadlab.org/research-specialist-applicants daily 0.75 2026-03-13 https://www.treadlab.org/veet-int daily 0.75 2025-08-09 https://www.treadlab.org/sky daily 0.75 2026-02-26 https://www.treadlab.org/research daily 0.75 2025-07-09 https://www.treadlab.org/research/dmfmri monthly 0.5 2020-09-22 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1600796642823-RHY9J2S1DUJ3C0CM9WT2/Website_images_fixed_Page_8.jpg Research - Neural Mechanisms of Motivation & Decision-Making - Neural Mechanisms of Motivation and Decision-Making The human striatum, and particularly dopaminergic neurons within the striatum, is believed to play a critical role in motivated decision-making and effort-discounting. However, the exact neural mechanisms underlying effort-based decision-making remain unknown. Specifically, adequate research has not been conducted to interpret and understand how the striatum responds to both effort and reward, as well as to their integration. This study aims to better understand neural responses to effort and reward during effort-based choice. Using functional magnetic resonance imaging (fMRI), individuals complete a sequential effort-based decision-making task. This design is unique in that it allows for the isolation of neural responses to effort or reward alone, as well as to subjective value estimates (reward discounted by effort). Additionally, this design can provide essential evidence about how the human striatum encodes effort and reward information, and if any regions responding to these separate pieces of information may predict future behavioral choices. Particularly, it can help clarify whether there is anatomical segregation in the regions that track costs and benefits or whether the same regions are responding to both pieces of information in a similar manner. https://www.treadlab.org/research/moa monthly 0.5 2020-09-22 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1600796440670-NGRL280L9DWJ171FASLU/Website_images_fixed_Page_3.jpg Research - Mechanisms of Anhedonia - Mechanisms of Anhedonia Anhedonia is known to involve motivational, anticipatory and hedonic components and has been related to deficits across multiple domains, including effort-based decision-making, reward anticipation, reinforcement learning and hedonic response. These different processes have distinct neurobiological mechanisms, possibly reflecting different subtypes of anhedonia with distinct neurobiology. Improving diagnosis and treatment for this symptom cluster depends on developing tools for better understanding, assessment, and classification of subtypes of anhedonia. The goals of this project are to use a combination of behavioral tasks, functional neuroimaging, and longitudinal data collection to identify biomarkers for different subtypes of anhedonia and to examine how these laboratory-based assessments reflect engagement in effortful activity and experience of reward in daily life. Project Funding: NIH F32 (PI: Cooper) https://www.treadlab.org/research/mmba monthly 0.5 2020-09-22 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1600796393246-93NWXCF905LWEUWW1JYE/Website_images_fixed_Page_2.jpg Research - Multi-Level Mechanisms of Behavioral Activation - Multi-Level Mechanisms of Behavioral Activation in Adolescent Depression Major Depressive Disorder (MDD), the initial episodes of which emerge most rapidly at ages 15-17, remains a major public health issue that necessitates successful experimental therapeutics research. Non-treated and unsuccessfully-treated adolescents with MDD suffer the most frequent and chronic subsequent depressive episodes. Behavioral Activtion (BA) is an apparently efficacious therapy for adolescent MDD although the mechansisms of BA’s efficacy remain unknown. Understanding mechanisms that engage targets of therapeutic change among adolescents is critical to determining when, how, and for whom BA can be an effective treatment. Through the use of extensive ecological momentary assessments (EMA), longitudinal fMRI collection to detect change in corticostriatal and corticolimbic circuitry, and novel computational, therapeutic, and neuroimaging techniques, this study aims to provide insight into the neural and behavioral targets of intervention for reducing avoidance behavior with BA. In turn, this knowledge can be used to inform future treatment modification and facilitate precision-medicine based psychotherapy interventions. https://www.treadlab.org/research/r21 monthly 0.5 2020-09-22 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1600792604792-H4VK1EAU5BXJTITBA7ZU/Website_images_fixed_Page_9.jpg Research - Transdiagnostic Immune Effects on Motivated Behavior - Transdiagnostic Immune Effects on Motivated Behavior The goal of this research is to determine whether inflammation represents a common (or distinct) mechanism for impairments in motivation across disorders of psychosis and mood. This project is poised to take advantage of a unique opportunity to build off of data collected by Dr. Deanna Barch at Washington University. Dr. Barch is recruiting a transdiagnostic sample to complete behavioral, ecological momentary assessment (EMA), and neuroimaging measures of EBDM. The TReAD Lab hopes to expand this work through the analysis of protein and genetic markers of inflammation and immunometabolism. https://www.treadlab.org/research/mover monthly 0.5 2020-09-22 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1600792119686-L0O185Z2SGR2NNRIZ1JF/Website_images_fixed_Page_5.png Research - Motivation for Reward in the Virtual Environment - Motivation for Reward in the Virtual Environment Understanding how the brain allocates effort in pursuit of rewards is a fundamental question of behavioral neuroscience. Modeling effort-based decision-making in the real world may require consideration of how effort-related information is incorporated as actions unfold within dynamic, naturalistic settings. This project uses a combination of virtual reality paradigms and functional neuroimaging to identify neural mechanisms supporting our willingness to work for rewards. https://www.treadlab.org/research/tms monthly 0.5 2024-03-11 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/6d308795-370b-4bc6-a947-35e18ace141c/BrainStudiesofDecisionMakingwithTemporalInterference.png Research - Brain Stimulation Studies of Decision Making Using Temporal Interference - Brain Stimulation Studies of Decision-Making Using Temporal Interference Prior research points to the involvement of several well-defined neural circuits in decision-making. However, much of the research of mechanisms of decision-making has been limited by the almost exclusive reliance on imaging study data, which are correlational. Direct brain interrogation to examine how particular brain regions, particularly hubs of these decision-making networks, are involved in making decisions will provide a stronger means of isolating possible causal roles for these regions across various processes. The goal of this project is to understand the effect of a non-invasive brain stimulation technique, Temporal Interference (TI), on performance in a series of cognition and decision-based behavioral tasks. Results from this study will not only provide a deeper understanding of the causal mechanisms of decision-making but will also serve to inform our understanding of altered decision-making commonly observed in psychiatric patients.Project Funding: APA Dissertation Research Award (PI: Arulpragasam), APF/COGDOP Graduate Research Scholarship (PI: Arulpragasam) https://www.treadlab.org/research/r00 monthly 0.5 2020-09-22 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1600791993671-T1KTM20WGGXBOFNQMG3K/Website_images_fixed_Page_4.png Research - Stress, Neuroplasticity, and Reinforcement Learning - Stress, Neuroplasticity, and Reinforcement Learning A core feature of MDD is reward-processing deficits in the form of decreased reward motivation and anhedonia. Importantly, alterations in prefrontal glutamatergic signaling have been recently linked to the symptom of anhedonia. This cardinal symptom of depression involves deficits in appropriate processing of reward information in MDD, as evidenced by poor reinforcement learning, blunted motivation, and impaired decision-making. Critically relevant to the proposed research, stress exerts deleterious effects over motivational and reward-processing systems, and can increase vulnerability for the development of reward-linked symptoms such as anhedonia, apathy and addiction. To address the relationship between stress, neuroplasticity and learning behavior, we will use pre and post-stress measures of MR Spectroscopy of medial prefrontal glutamate and GABA in combination with fMRI during a reward-learning paradigm. Project Funding: NIMH R00 (PI: Treadway) https://www.treadlab.org/research/inflix monthly 0.5 2020-09-22 https://images.squarespace-cdn.com/content/v1/5eac3432211fff29b8d42b46/1600791855180-6QWACQTJXK5UYTY1NXYK/Slide1.png Research - Inflammatory Markers of Depression - INFLAMMATION, MOTIVATION, & DOPAMINE Prior work suggests that dopamine dysfunction may be implicated in motivational impairments in depression. If this is true, then it is important to ask why this might be the case. One candidate mechanism is inflammation. Through a combination of functional and neurochemical imaging in a sample of depressed patients with varying levels of inflammation, this project will determine the extent to which inflammation contributes to motivational symptoms and whether corticostriatal circuit function mediates this relationship. The goal of this project is to help validate the immune system and corticostriatal reward circuits as important targets for the development of novel anti-inflammatory treatment and prevention strategies, which in turn can be used to personalize treatments for patients with high inflammation and motivational deficits. Importantly, we do not propose this model as a means of accounting for all forms of anhedonic symptoms; rather, we suggest this as a possible mechanism that may occur in the context of high inflammation and altered dopamine-dependent corticostriatal network functions. 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