Publications

2018

The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology. EL Belleau, MT Treadway, and DA Pizzagalli. Biological Psychiatry 18 (2018), 10.1016/j.biopsych.2018.09.031.

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Anhedonia in depression: biological mechanisms and computational models. JA Cooper, AR Arulpragasam, and MT Treadway. Current Opinion in Behavioral Sciences 22 (2018), 128-135.

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Common and dissociable neural activity following mindfulness-based stress reduction and relaxation response programs. G Sevinc, BK Hölzel, J Hashmi, J Greenberg, A McCallister, MT Treadway, ML Schneider, JA Dusek, J Carmody, and SW Lazar. Psychosomatic Medicine 80 (2018), 439-451.

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Examining the role of repetitive negative thinking in relations between positive and negative aspects of self-compassion and symptom improvement during intensive treatment. LP Wadsworth, M Forgeard, KJ Hsu, S Kertz, MT Treadway, and T Björgvinsson. Cognitive Therapy and Research 42 (2018), 236-249.

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Corticoinsular circuits encode subjective value expectation and violation for effortful goal-directed behavior. AR Arulpragasam, JA Cooper, MR Nuutinen, and MTTreadway. Proceedings of the National Academy of Sciences 115 (2018), E5233-E5242.

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Inflammation-associated alterations in corticostriatal circuit function in breast cancer: relationship with motivational and motor deficits and fatigue. J Felger, MT Treadway, Z Li, E Haroon, MA Torres, and AH Miller.Psychosomatic Medicine 80, (2018), A145-A146.



Social motivation in schizophrenia: the impact of oxytocin on vigor in the context of social and nonsocial reinforcement. D Fulford, MT Treadway, and J Woolley. Journal of Abnormal Psychology 127 (2018), 116-128.

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2017

Willingness to expend effort toward reward and extreme ambitions in bipolar I disorder. SL Johnson, BA Swerdlow, MT Treadway, JA Tharp, and CS Carver. Clinical Psychological Science 5 (2017), 943-951.

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Frontostriatal and dopamine markers of individual differences in reinforcement learning: a multi-modal investigation. RH Kaiser, MT Treadway, DW Witten, P Kumar, F Goer, L Murray, M Beltzer, P Pechtel, A Whitton, AL Cohen, NM Alpert, GE Fakhri, MD Normandin, and DA Pizzagalli. Cerebral Cortex (2017), 1-10.

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Reduced willingness to expend effort for reward in obesity: link to adherence to a 3‐month weight loss intervention. F Mata, MT Treadway, A Kwok, H Truby, M Yücel, JC Stout, and A Verdejo‐Garcia. Obesity 25 (2017), 1676-1681.

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Distinct trajectories of cortisol response to prolonged acute stress are linked to affective responses and hippocampal gray matter volume in healthy females. R Admon, MT Treadway, L Valeri, M Mehta, S Douglas and D. Pizzagalli Journal of Neuroscience (2017), 1175-17.

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Working hard for oneself or others: Effects of oxytocin on reward motivation in social anxiety disorder. JA Fanga, MT Treadway, and SG Hofmann. Biological Psychology 127 (2017), 157-162.

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Reward processing, neuroeconomics, and psychopathology. DH Zald and MT Treadway. Annual Review of Clinical Psychology 13 (2017), 471-496.

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Inflammation effects on motivation and motor activity: role of dopamine. JC Felger and MT Treadway. Neuropsychopharmacology 42 (2017), 216-241.

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Lipopolysaccharide alters motivated behavior in a monetary reward task: a randomized trial. J Lasselin, MT Treadway, TE Lacourt, A Soop, MJ Olsson, B Karshikoff, S Paues-Göranson, J Axelsson, R Dantzer, and M Lekander. Neuropsychopharmacology 42 (2017), 801–810.

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Vicarious effort-based decision-making in autism spectrum disorders. MG Mosner, JL Kinard, S McWeeny, JS Shah, ND Markiewitz, CR Damiano‑Goodwin, MR Burchinal, HJV Rutherford, RK Greene, MT Treadway, and GS Dichter. Journal of Autism and Developmental Disorders 47 (2017), 2992-3006.

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Association between interleukin-6 and striatal prediction-error signals following acute stress in healthy female participants. MT Treadway, R Admon, A Arulpragasam, M Mehta, S Douglas, G Vitaliano, DP Olson, JA Cooper, and DA Pizzagalli. Biological Psychiatry 82 (2017), 570-577.

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2016

Isolating biomarkers for symptomatic states: considering symptom–substrate chronometry. MT Treadway and CV Leonard. Molecular Psychiatry 21 (2016), 1180–1187.

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Inflammation effects on motivation and motor activity: role of dopamine. JC Felger and MT Treadway. Neuropsychopharmacology REVIEWS (2016) 1–26.

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Inefficient effort allocation and negative symptoms in individuals with schizophrenia. JM McCarthy, MT Treadway, ME Bennet, and JL Blanchard. Schizophrenia Research 170 (2016), 278-284.

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Clashing Diagnostic Approaches: DSM-ICD versus RDoC. SO Lilienfeld and MT Treadway. Annual Review of Clinical Psychology 12 (2016), 435-463.

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Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder. DR Goldsmith, E Haroon, BJ Woolwine, MY Jung, EC Wommack, PD Harvey, MT Treadway, JC Felger, and AH Miller. Brain, Behavior, and Immunity 56 (2016), 281-288.

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Effect of failure/success feedback and the moderating influence of personality on reward motivation. D Anand, KA Oehlberg, MT Treadway, and R Nusslock. Cognition and Emotion 30 (2016), 458-471.

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Network analysis of depression and anxiety symptom relationships in a psychiatric sample. C Beard, AJ Millner, MJC Forgeard, EI Fried, KJ Hsu, MT Treadway, CV Leonard, SJ Kertz, and T Björgvinsson. Psychological Medicine 46 (2016), 3359-3369.

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2015

From Blame to Punishment: Disrupting Prefrontal Cortex Activity Reveals Norm Enforcement Mechanisms. JW Buckholtz, JW Martin, MT Treadway, K Jan, DH Zald, O Jones, R Marois. Neuron 87(6), 1369-1380, 2015.

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Perceived life stress exposure modulates reward-related medial prefrontal cortex responses to acute stress in depression. P Kumar, GM Slavich, LH Berghorst, MT Treadway, NH Brooks, SJ Dutra, Journal of Affective Disorders 180, 104-111, 2015.

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Trait Anticipatory Pleasure Predicts Effort Expenditure for Reward. Geaney JT, Treadway MT, Smillie LD (2015) PLoS ONE 10(6): e0131357. doi:10.1371/journal.pone.0131357

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Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 1—Psychometric Characteristics of 5 Paradigms, L. Felice Reddy, William P. Horan, Deanna M. Barch, Robert W. Buchanan, Eduardo Dunayevich, James M. Gold, Naomi Lyons, Stephen R. Marder, Michael T. Treadway, Jonathan K. Wynn, Jared W. Young, and Michael F. Green.
Schizophrenia Bulletin 2015 : sbv089v1-sbv089.

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Motivation and effort in individuals with social anhedonia. JM McCarthy, MT Treadway, JJ Blanchard. Schizophrenia Research 165 (1), 70-75, 2015.

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Effect of Social Influence on Effort-Allocation for Monetary Rewards in Psychopathology. JM Gilman, MT Treadway, MT Curran, V Calderon, AE Evins, PLoS ONE, 10(5), 2015.

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Neural Mechanisms of Effort-based Decision-making in Psychopathology. M Treadway, JW Martin, D Cole, R Tennyson, M Memmer, RC Shelton, …Biological Psychiatry, 77 (9), 14S-14S, 2015.



Impaired effort allocation in patients with schizophrenia. MT Treadway, JS Peterman, DH Zald, S Park Schizophrenia Research, 161 (2), 382-385, 2015.

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Effect of failure/success feedback and the moderating influence of personality on reward motivation. D Anand, KA Oehlberg, MT Treadway, R Nusslock. Cognition and Emotion, 1-14, 2015.

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Illness Progression, Recent Stress, and Morphometry of Hippocampal Subfields and Medial Prefrontal Cortex in Major Depression. MT Treadway, ML Waskom, DG Dillon, AJ Holmes, MTM Park, … Biological Psychiatry. 2015

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The Neurobiology of Motivational Deficits in Depression--An Update on Candidate Pathomechanisms. MT Treadway Current Topics in Behavioral Neurosciences . 2015

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Reward Processing Dysfunction in Major Depression, Bipolar Disorder, and Schizophrenia. AE Whitton, MT Treadway, DA Pizzagalli Current Opinion In Psychiatry 28 (1), 7-12, 2015.

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2014

Effort, anhedonia, and function in schizophrenia: Reduced effort allocation predicts amotivation and functional impairment. DM Barch, MT Treadway, N Schoen. Journal of Abnormal Psychology 123 (2), 387, 2014.

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Corticolimbic gating of emotion-driven punishment. MT Treadway, JW Buckholtz, JW Martin, K Jan, CL Asplund, MR Ginther, Nature Neuroscience 17 (9), 1270-1275. 2014.

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Imaging the pathophysiology of major depressive disorder-from localist models to circuit-based analysis. MT Treadway, DA Pizzagalli. Biology of Mood and Anxiety Disorders 4 (1), 5. 2014.

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Effort, Motivation And Reward Learning In Schizophrenia: Relationships To Amotivation And Functional Impairment. DM Barch, M Treadway, N Schoen, E Dowd. Schizophrenia Research 153, S39. 2014.

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Translational Models of Dopaminergic Mechanisms for Motivational Deficits in Anhedonic Patients. MT Treadway, DH Zald. Anhedonia: A Comprehensive Handbook Volume I, 107-117. 2014.

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2013

Parsing anhedonia translational models of reward-processing deficits in psychopathology. MT Treadway, DH Zald. Current directions in psychological science 22 (3), 244-249, 2013.

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Perceived stress predicts altered reward and loss feedback processing in medial prefrontal cortex. MT Treadway, JW Buckholtz, DH Zald. Frontiers in human neuroscience 7, 2013.

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2012

Dopaminergic mechanisms of individual differences in human effort-based decision-making. MT Treadway, JW Buckholtz, RL Cowan, ND Woodward, R Li, MS Ansari. The Journal of Neuroscience 32 (18), 6170-6176, 2012.

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Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia. MT Treadway, NA Bossaller, RC Shelton, DH Zald. Journal of Abnormal Psychology 121 (3), 553, 2012.

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Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions. CR Damiano, J Aloi, M Treadway, JW Bodfish, GS Dichter. J Neurodevelopmental Disord 4, 13, 2012.

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Caffeine increases psychomotor performance on the effort expenditure for rewards task. MC Wardle, MT Treadway, H de Wit. Pharmacology Biochemistry and Behavior 102 (4), 526-531, 2012.

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A Thalamocorticostriatal Dopamine Network for Psychostimulant-Enhanced Human Cognitive Flexibility. GR Samanez-Larkin, JW Buckholtz, RL Cowan, ND Woodward, R Li. Biological Psychiatry, 2012.

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Parsing anhedonia: effort-based decision-making as a translational model of motivational deficits in Major Depressive Disorder. MT Treadway. Vanderbilt University. 2012.

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2011

Reconsidering anhedonia in depression: lessons from translational neuroscience. MT Treadway, DH Zald. Neuroscience & Biobehavioral Reviews35 (3), 537-555, 2011.

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Amping up effort: effects of d-amphetamine on human effort-based decision-making. MC Wardle, MT Treadway, LM Mayo, DH Zald, H de Wit. The Journal of Neuroscience 31 (46), 16597-16602, 2011.

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Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational and Neural Networks conference. VB McGinty, BY Hayden, SR Heilbronner, EC Dumont, SM Graves. Behavioural Brain Research, 2011.

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On the Use and Misuse of Genomic and Neuroimaging Science in Forensic Psychiatry: Current Roles and Future Directions. MT Treadway, JW Buckholtz. Child and Adolescent Psychiatric Clinics of North America 20 (3), 533-546, 2011.

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2010 and earlier...

Dopaminergic network differences in human impulsivity. JW Buckholtz, MT Treadway, RL Cowan, ND Woodward, R Li, MS Ansari. Science 329 (5991), 532-532, 2010.

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Meditation and neuroplasticity: Using mindfulness to change the brain. MT Treadway, SW Lazar Assessing mindfulness and acceptance processes in clients: Illuminating the, 2010.

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Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. JW Buckholtz, MT Treadway, RL Cowan, ND Woodward, SD Benning. Nature Neuroscience 13 (4), 419-421, 2010.

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Worth the ‘EEfRT’? The effort expenditure for rewards task as an objective measure of motivation and anhedonia. MT Treadway, JW Buckholtz, AN Schwartzman, WE Lambert, DH Zald. PLoS One 4 (8), e6598, 2009.

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Early adverse events, HPA activity and rostral anterior cingulate volume in MDD. MT Treadway, MM Grant, Z Ding, SD Hollon, JC Gore, RC Shelton. PloS One 4 (3), e4887, 2009.

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Meditation experience is associated with increased cortical thickness. SW Lazar, CE Kerr, RH Wasserman, JR Gray, DN Greve, MT Treadway. Neuroreport 16 (17), 1893, 2005.

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